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Article

Wise, a context-dependent activator and inhibitor of Wnt signalling.

Development (Cambridge, England) - 1 Sept 2003

Itasaki Nobue, Jones C Michael, Mercurio Sara, Rowe Alison, Domingos Pedro M, Smith James C, Krumlauf Robb

Abstract excerpt

We have isolated a novel secreted molecule, Wise, by a functional screen for activities that alter the anteroposterior character of neuralised Xenopus animal caps. Wise encodes a secreted protein capable of inducing posterior neural markers at a distance. Phenotypes arising from ectopic expression or depletion of Wise resemble those obtained when Wnt signalling is altered. In animal cap assays, posterior neural...

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Identifiers

PMID: 12900447
DOI: 10.1242/dev.00674

Genes

LRP6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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