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Article

Wise regulates bone deposition through genetic interactions with Lrp5.

PloS one - 1 Jan 2014

Ellies Debra L, Economou Androulla, Viviano Beth, Rey Jean-Philippe, Paine-Saunders Stephenie, Krumlauf Robb, Saunders Scott

Abstract excerpt

In this study using genetic approaches in mouse we demonstrate that the secreted protein Wise plays essential roles in regulating early bone formation through its ability to modulate Wnt signaling via interactions with the Lrp5 co-receptor. In Wise-/- mutant mice we find an increase in the rate of osteoblast proliferation and a transient increase in bone mineral density. This change in proliferation is dependent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24789067
DOI: 10.1371/journal.pone.0096257
PMCID: PMC4006890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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