Article
Rare X Chromosome Abnormalities in Systemic Lupus Erythematosus and Sjögren's Syndrome.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Nov 2017
Sharma Rohan, Harris Valerie M, Cavett Joshua, Kurien Biji T, Liu Ke, Koelsch Kristi A, Fayaaz Anum, Chaudhari Kaustubh S, Radfar Lida, Lewis David, Stone Donald U, Kaufman C Erick, Li Shibo, Segal Barbara, Wallace Daniel J, Weisman Michael H, Venuturupalli Swamy, Kelly Jennifer A, Pons-Estel Bernardo, Jonsson Roland, Lu Xianglan, Gottenberg Jacques-Eric, Anaya Juan-Manuel, Cunninghame-Graham Deborah S, Huang Andrew J W, Brennan Michael T, Hughes Pamela, Alevizos Ilias, Miceli-Richard Corinne, Keystone Edward C, Bykerk Vivian P, Hirschfield Gideon, Nordmark Gunnel, Bucher Sara Magnusson, Eriksson Per, Omdal Roald, Rhodus Nelson L, Rischmueller Maureen, Rohrer Michael, Wahren-Herlenius Marie, Witte Torsten, Alarcón-Riquelme Marta, Mariette Xavier, Lessard Christopher J, Harley John B, Ng Wan-Fai, Rasmussen Astrid, Sivils Kathy L, Scofield R Hal
Abstract excerpt
OBJECTIVE: Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) are related by clinical and serologic manifestations as well as genetic risks. Both diseases are more commonly found in women than in men, at a ratio of ~10 to 1. Common X chromosome aneuploidies, 47,XXY and 47,XXX, are enriched among men and women, respectively, in either disease, suggesting a dose effect on the X chromosome. METHODS: We...
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