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Sjögren's syndrome X‐chromosome dose effect: An epigenetic perspective

10 Jan 2018

Abstract excerpt

Sjögren's syndrome (SS) is a chronic autoimmune disease affecting exocrine glands leading to mouth and eyes dryness. The extent to which epigenetic DNA methylation changes are responsible for an X-chromosome dose effect has yet to be determined. Our objectives were to (i) describe how epigenetic DNA methylation changes could explain an X-chromosome dose effect in SS for women with normal 46,XX genotype and (ii)...

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PMID: 29316023
DOI: 10.1111/odi.12825

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