Article
Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome.
Clinical immunology (Orlando, Fla.) - 1 Jul 2016
Harris Valerie M, Sharma Rohan, Cavett Joshua, Kurien Biji T, Liu Ke, Koelsch Kristi A, Rasmussen Astrid, Radfar Lida, Lewis David, Stone Donald U, Kaufman C Erick, Li Shibo, Segal Barbara, Wallace Daniel J, Weisman Michael H, Venuturupalli Swamy, Kelly Jennifer A, Alarcon-Riquelme Marta E, Pons-Estel Bernardo, Jonsson Roland, Lu Xianglan, Gottenberg Jacques-Eric, Anaya Juan-Manuel, Cunninghame-Graham Deborah S, Huang Andrew J W, Brennan Michael T, Hughes Pamela, Alevizos Ilias, Miceli-Richard Corinne, Keystone Edward C, Bykerk Vivian P, Hirschfield Gideon, Xie Gang, Siminovitch Katherine A, Ng Wan-Fai, Nordmark Gunnel, Bucher Sara Magnusson, Eriksson Per, Omdal Roald, Rhodus Nelson L, Rischmueller Maureen, Rohrer Michael, Wahren-Herlenius Marie, Witte Torsten, Mariette Xavier, Lessard Christopher J, Harley John B, Sivils Kathy L, Scofield R Hal
Abstract excerpt
Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy...
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