Article
Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome.
Arthritis and rheumatism - 1 Aug 2008
Scofield R Hal, Bruner Gail R, Namjou Bahram, Kimberly Robert P, Ramsey-Goldman Rosalind, Petri Michelle, Reveille John D, Alarcón Graciela S, Vilá Luis M, Reid Jeff, Harris Bryan, Li Shibo, Kelly Jennifer A, Harley John B
Abstract excerpt
OBJECTIVE: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that predominantly affects women. Despite isolated reports of patients with coexisting Klinefelter's syndrome (47,XXY) and SLE, no association of Klinefelter's syndrome with SLE or any other autoimmune disease has been established. The present study was undertaken to investigate the prevalence of Klinefelter's syndrome in a large...
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