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Article

Sex chromosome aneuploidies among men with systemic lupus erythematosus.

Journal of autoimmunity - 1 May 2012

Dillon Skyler P, Kurien Biji T, Li Shibo, Bruner Gail R, Kaufman Kenneth M, Harley John B, Gaffney Patrick M, Wallace Daniel J, Weisman Michael H, Scofield R Hal

Abstract excerpt

About 90% of patients with systemic lupus erythematosus (SLE) are female. We hypothesize that the number of X chromosomes, not sex, is a determinate of risk of SLE. Number of X chromosomes was determined by single nucleotide typing and then confirmed by karyotype or fluorescent in situ hybridization in a large group of men with SLE. Presence of an sry gene was assessed by RT-PCR. We calculated 96% confidence...

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Topics

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Share to Aneuploidy
Share to Chromosomes, Human, X

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lupus Erythematosus, Systemic

Share to Polymorphism, Single Nucleotide

Share to Receptors, Androgen

Share to Sex Chromosome Aberrations

Share to Sex-Determining Region Y Protein

Share to Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 22154021
DOI: 10.1016/j.jaut.2011.10.004
PMCID: PMC3309073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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