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Article

Cellular prion protein (PrPC) in the development of Merlin-deficient tumours.

Oncogene - 2 Nov 2017

Provenzano L, Ryan Y, Hilton D A, Lyons-Rimmer J, Dave F, Maze E A, Adams C L, Rigby-Jones R, Ammoun S, Hanemann C O

Abstract excerpt

Loss of function mutations in the neurofibromatosis Type 2 (NF2) gene, coding for a tumour suppressor, Merlin, cause multiple tumours of the nervous system such as schwannomas, meningiomas and ependymomas. These tumours may occur sporadically or as part of the hereditary condition neurofibromatosis Type 2 (NF2). Current treatment is confined to (radio) surgery and no targeted drug therapies exist. NF2 mutations...

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Identifiers

PMID: 28692055
DOI: 10.1038/onc.2017.200

Genes

TRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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