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Article

Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1.

The American journal of pathology - 1 Nov 2016

Wang Yiwei, Yu Shuiliang, Huang Dan, Cui Min, Hu Huankai, Zhang Lihua, Wang Weihuan, Parameswaran Neetha, Jackson Mark, Osborne Barbara, Bedogni Barbara, Li Chaoyang, Sy Man-Sun, Xin Wei, Zhou Lan

Abstract excerpt

Up-regulation of human prion protein (PrP) in patients with pancreatic ductal adenocarcinoma (PDAC) is associated with a poor prognosis. However, the underlying molecular mechanism of PrP-mediated tumorigenesis is not completely understood. In this study, we found that PDAC cell lines can be divided into either PrP high expresser or PrP low expresser. In addition to filamin A (FLNA), PrP interacts with Notch1,...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27639164
DOI: 10.1016/j.ajpath.2016.07.010
PMCID: PMC6667968

Genes

FLNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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