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Article

Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment.

Pharmacogenetics and genomics - 1 Nov 2017

Marcath Lauren A, Deal Allison M, Van Wieren Emily, Danko William, Walko Christine M, Ibrahim Joseph G, Weck Karen E, Jones David R, Desta Zeruesenay, McLeod Howard L, Carey Lisa A, Irvin William J, Hertz Daniel L

Abstract excerpt

OBJECTIVES: Tamoxifen bioactivation to endoxifen is mediated primarily by CYP2D6; however, considerable variability remains unexplained. Our aim was to perform a comprehensive assessment of the effect of genetic variation in tamoxifen-relevant enzymes and transporters on steady-state endoxifen concentrations. PATIENTS AND METHODS: Comprehensive genotyping of CYP enzymes and transporters was performed using the...

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Identifiers

PMID: 28877533
DOI: 10.1097/FPC.0000000000000311
PMCID: PMC5659294

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