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DNA Methylation of ADME Genes

27 Jan 2016

Abstract excerpt

The epigenetic regulation of expression of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs contributes to interindividual variability in drug response. Epigenetic mechanisms include DNA methylation, histone modifications, and miRNAs. This review systematically outlines the influence of DNA methylation on ADME gene expression and highlights the consequences for...

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PMID: 27061006
DOI: 10.1002/cpt.343

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