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Article

ADCY5 couples glucose to insulin secretion in human islets.

Diabetes - 1 Sept 2014

Hodson David J, Mitchell Ryan K, Marselli Lorella, Pullen Timothy J, Gimeno Brias Silvia, Semplici Francesca, Everett Katy L, Cooper Dermot M F, Bugliani Marco, Marchetti Piero, Lavallard Vanessa, Bosco Domenico, Piemonti Lorenzo, Johnson Paul R, Hughes Stephen J, Li Daliang, Li Wen-Hong, Shapiro A M James, Rutter Guy A

Abstract excerpt

Single nucleotide polymorphisms (SNPs) within the ADCY5 gene, encoding adenylate cyclase 5, are associated with elevated fasting glucose and increased type 2 diabetes (T2D) risk. Despite this, the mechanisms underlying the effects of these polymorphic variants at the level of pancreatic β-cells remain unclear. Here, we show firstly that ADCY5 mRNA expression in islets is lowered by the possession of risk alleles...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24740569
DOI: 10.2337/db13-1607
PMCID: PMC4141364

Genes

ADCY5

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