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Autophagy augments the self-renewal of lung cancer stem cells by the degradation of ubiquitinated p53

19 Jan 2021

Abstract excerpt

It has been postulated that cancer stem cells (CSCs) are involved in all aspects of human cancer, although the mechanisms governing the regulation of CSC self-renewal in the cancer state remain poorly defined. In the literature, both the pro- and anti-oncogenic activities of autophagy have been demonstrated and are context-dependent. Mounting evidence has shown augmentation of CSC stemness by autophagy, yet...

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PMID: 33468994
DOI: 10.1038/s41419-021-03392-6

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