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Article

Melatonin and its derivative disrupt cancer stem-like phenotypes of lung cancer cells via AKT downregulation.

Clinical and experimental pharmacology & physiology - 1 Dec 2021

Phiboonchaiyanan Preeyaporn Plaimee, Puthongking Ploenthip, Chawjarean Verisa, Harikarnpakdee Saraporn, Sukprasansap Monruedee, Chanvorachote Pithi, Priprem Aroonsri, Govitrapong Piyarat

Abstract excerpt

Cancer stem cells (CSCs), a small subpopulation of tumour cells, have properties of self-renewal and multipotency, which drive cancer progression and resistance to current treatments. Compounds potentially targeting CSCs have been recently developed. This study shows how melatonin, an endogenous hormone synthesised by the pineal gland, and its derivative suppress CSC-like phenotypes of human non-small cell lung...

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PMID: 34396568
DOI: 10.1111/1440-1681.13572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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