Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals.

Scientific reports - 3 Jul 2017

Donati Benedetta, Dongiovanni Paola, Romeo Stefano, Meroni Marica, McCain Misti, Miele Luca, Petta Salvatore, Maier Silvia, Rosso Chiara, De Luca Laura, Vanni Ester, Grimaudo Stefania, Romagnoli Renato, Colli Fabio, Ferri Flaminia, Mancina Rosellina Margherita, Iruzubieta Paula, Craxi Antonio, Fracanzani Anna Ludovica, Grieco Antonio, Corradini Stefano Ginanni, Aghemo Alessio, Colombo Massimo, Soardo Giorgio, Bugianesi Elisabetta, Reeves Helen, Anstee Quentin M, Fargion Silvia, Valenti Luca

Abstract excerpt

Nonalcoholic fatty liver disease (NAFLD) represents an emerging cause of hepatocellular carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C > T MBOAT7/TMC4 variant predisposes to progressive NAFLD, but the impact on hepatic carcinogenesis is unknown. In Italian NAFLD patients, the rs641738 T allele was associated with NAFLD-HCC (OR 1.65, 1.08-2.55; n = 765), particularly in those without...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyltransferases
Share to Carcinoma, Hepatocellular
Share to Gene Expression Regulation
Share to Italy
Share to Liver Cirrhosis
Share to Liver Neoplasms
Share to Membrane Proteins
Share to Non-alcoholic Fatty Liver Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 28674415
DOI: 10.1038/s41598-017-04991-0
PMCID: PMC5495751

Genes

MBOAT7
PNPLA3
TMC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals.PMID 28674415Read ↗

rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis.Semantic proximity Read ↗

Lack of evidence supporting a role of TMC4-rs641738 missense variant-MBOAT7- intergenic downstream variant-in the Susceptibility to Nonalcoholic Fatty Liver Disease.Semantic proximity Read ↗

rs641738C>T near<i>MBOAT7</i>is positively associated with liver fat, ALT, and histological severity of NAFLD: a meta-analysisSemantic proximity Read ↗

MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort.Semantic proximity Read ↗

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.Semantic proximity Read ↗

MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C.Semantic proximity Read ↗

MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population.Semantic proximity Read ↗

MBOAT7 down-regulation by genetic and environmental factors predisposes to MAFLD.Semantic proximity Read ↗

The membrane-bound O-acyltransferase domain-containing 7 variant rs641738 increases inflammation and fibrosis in chronic hepatitis B.Semantic proximity Read ↗

Loss of hepatic Mboat7 leads to liver fibrosis.Semantic proximity Read ↗

Genetic determinants of hepatic steatosis and serum cytokeratin-18 fragment levels in Taiwanese children.Semantic proximity Read ↗

Genetic variants underlying precancerous conditions of hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.