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Article

Lack of evidence supporting a role of TMC4-rs641738 missense variant-MBOAT7- intergenic downstream variant-in the Susceptibility to Nonalcoholic Fatty Liver Disease.

Scientific reports - 23 Mar 2018

Sookoian Silvia, Flichman Diego, Garaycoechea Martin E, Gazzi Carla, Martino Julio San, Castaño Gustavo O, Pirola Carlos J

Abstract excerpt

Current knowledge on the genetic basis of nonalcoholic fatty liver disease (NAFLD) suggests that variants contributing not only to the disease predisposition but histological severity as well are located in genes that regulate lipid metabolism. We explored the role of rs641738 C/T located in TMC4 (transmembrane channel-like 4) exon 1 (p.Gly17Glu) and 500 bases- downstream of MBOAT7 gene (TMC4/MBOAT7), in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Acyltransferases
Share to Case-Control Studies
Share to Gene Frequency
Share to Genetic Predisposition to Disease
Share to Membrane Proteins
Share to Mutation, Missense
Share to Non-alcoholic Fatty Liver Disease
Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 29572551
DOI: 10.1038/s41598-018-23453-9
PMCID: PMC5865142

Genes

MBOAT7
TMC4

Variants

rs641738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of evidence supporting a role of TMC4-rs641738 missense variant-MBOAT7- intergenic downstream variant-in the Susceptibility to Nonalcoholic Fatty Liver Disease.PMID 29572551Read ↗

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