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Article

Genetic Diversity in Bronchial Asthma Susceptibility: Exploring the Role of Vitamin D Receptor Gene Polymorphisms in Varied Geographic Contexts.

International journal of molecular sciences - 5 Feb 2024

Paramonova Natalia, Trapina Ilva, Gradauskiene Sitkauskiene Brigita, Plavina Samanta, Tamasauskiene Laura, Bastyte Daina, Rumba-Rozenfelde Ingrida, Tapina Sandra, Stakaitiene Ieva, Ugenskiene Rasa, Shih-Hsin Wu Lawrence, Wang Jiu-Yao, Hsieh Miao-Hsi, Chen Pei-Chi, Sjakste Nikolajs

Abstract excerpt

Bronchial asthma (BA) exhibits varying prevalence across global populations, prompting a comprehensive investigation into genetic and environmental determinants. Vitamin D is a potent immunomodulator capable of suppressing inflammatory signals in several cell types involved in the asthmatic response; it exerts effects on the immune system by binding to the nuclear vitamin D receptor (VDR). VDR gene genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38339221
DOI: 10.3390/ijms25031943
PMCID: PMC10856277

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