Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid and cost-effective high-throughput sequencing for identification of germline mutations of BRCA1 and BRCA2.

Journal of human genetics - 1 Apr 2017

Ahmadloo Somayeh, Nakaoka Hirofumi, Hayano Takahide, Hosomichi Kazuyoshi, You Hua, Utsuno Emi, Sangai Takafumi, Nishimura Motoi, Matsushita Kazuyuki, Hata Akira, Nomura Fumio, Inoue Ituro

Abstract excerpt

Genetic testing for breast cancer predisposing genes, BRCA1 and BRCA2, can take advantage for early identification of carriers with pathogenic germline mutations. However, conventional approaches based on Sanger sequencing are laborious and expensive. Next-generation sequencing technology has a great impact on investigation of medical genomics and now applied clinical genetics. We provide a protocol based on a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to Breast Neoplasms

Share to Cost-Benefit Analysis

Share to Genetic Predisposition to Disease

Share to Germ-Line Mutation

Share to High-Throughput Nucleotide Sequencing

Source

Identifiers

PMID: 28179634
DOI: 10.1038/jhg.2017.5

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid and cost-effective high-throughput sequencing for identification of germline mutations of BRCA1 and BRCA2.PMID 28179634Read ↗

Analysis of BRCA1/2 mutation spectrum and prevalence in unselected Chinese breast cancer patients by next-generation sequencing.Semantic proximity Read ↗

Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing.Semantic proximity Read ↗

The spectrum of BRCA mutations and characteristics of BRCA-associated breast cancers in China: Screening of 2,991 patients and 1,043 controls by next-generation sequencing.Semantic proximity Read ↗

Prevalence and Spectrum of BRCA1/2 Germline Mutations in Women with Breast Cancer in China Based on Next-Generation Sequencing.Semantic proximity Read ↗

Long-range PCR and next-generation sequencing of BRCA1 and BRCA2 in breast cancer.Semantic proximity Read ↗

Rapid and cost effective screening of breast and ovarian cancer genes using novel sequence capture method in clinical samples.Semantic proximity Read ↗

Gene Panel Sequencing in a Chinese High-risk Breast Cancer CohortSemantic proximity Read ↗

Evaluation of an amplicon-based next-generation sequencing panel for detection of BRCA1 and BRCA2 genetic variants.Semantic proximity Read ↗

Germline and somatic mutation profile in Cancer patients revealed by a medium-sized pan-Cancer panel.Semantic proximity Read ↗

The frequency and pathogenicity of BRCA1 and BRCA2 variants in the general Japanese population.Semantic proximity Read ↗

Clinical Next-Generation Sequencing Pipeline Outperforms a Combined Approach Using Sanger Sequencing and Multiplex Ligation-Dependent Probe Amplification in Targeted Gene Panel Analysis.Semantic proximity Read ↗

Next-generation sequencing of the BRCA1 and BRCA2 genes for the genetic diagnostics of hereditary breast and/or ovarian cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.