Article
Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis.
Cancer research - 1 Sept 2017
Young Arabella, Ngiow Shin Foong, Madore Jason, Reinhardt Julia, Landsberg Jennifer, Chitsazan Arash, Rautela Jai, Bald Tobias, Barkauskas Deborah S, Ahern Elizabeth, Huntington Nicholas D, Schadendorf Dirk, Long Georgina V, Boyle Glen M, Hölzel Michael, Scolyer Richard A, Smyth Mark J
Abstract excerpt
Increasing evidence exists for the role of immunosuppressive adenosine in promoting tumor growth and spread in a number of cancer types, resulting in poor clinical outcomes. In this study, we assessed whether the CD73-adenosinergic pathway is active in melanoma patients and whether adenosine restricts the efficacy of clinically approved targeted therapies for commonly mutated BRAFV600E melanoma. In AJCC stage III...
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