Article
Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface.
PLoS computational biology - 1 Jan 2018
Rahimova Rahila, Fontanel Simon, Lionne Corinne, Jordheim Lars Peter, Peyrottes Suzanne, Chaloin Laurent
Abstract excerpt
The ecto-5'-nucleotidase CD73 plays an important role in the production of immune-suppressive adenosine in tumor micro-environment, and has become a validated drug target in oncology. Indeed, the anticancer immune response involves extracellular ATP to block cell proliferation through T-cell activation. However, in the tumor micro-environment, two extracellular membrane-bound enzymes (CD39 and CD73) are...
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