Article
BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development.
Developmental biology - 1 Sept 2017
Pan Haichun, Zhang Honghao, Abraham Ponnu, Komatsu Yoshihiro, Lyons Karen, Kaartinen Vesa, Mishina Yuji
Abstract excerpt
Craniosynostosis is caused by premature fusion of one or more sutures in an infant skull, resulting in abnormal facial features. The molecular and cellular mechanisms by which genetic mutations cause craniosynostosis are incompletely characterized, and many of the causative genes for diverse types of syndromic craniosynostosis have not yet been identified. We previously demonstrated that augmentation of BMP...
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