Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2013

Komatsu Yoshihiro, Yu Paul B, Kamiya Nobuhiro, Pan Haichun, Fukuda Tomokazu, Scott Gregory J, Ray Manas K, Yamamura Ken-Ichi, Mishina Yuji

Abstract excerpt

Craniosynostosis describes conditions in which one or more sutures of the infant skull are prematurely fused, resulting in facial deformity and delayed brain development. Approximately 20% of human craniosynostoses are thought to result from gene mutations altering growth factor signaling; however, the molecular mechanisms by which these mutations cause craniosynostosis are incompletely characterized, and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein Receptors, Type I
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Craniosynostoses

Share to Mice, Transgenic

Share to Neural Crest

Share to Pyrazoles

Share to Pyrimidines

Share to Smad Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23281127
DOI: 10.1002/jbmr.1857
PMCID: PMC3638058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice.PMID 23281127Read ↗

BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development.Semantic proximity Read ↗

Genetic basis of potential therapeutic strategies for craniosynostosis.Semantic proximity Read ↗

Mesodermal expression of Fgfr2S252W is necessary and sufficient to induce craniosynostosis in a mouse model of Apert syndrome.Semantic proximity Read ↗

Increased FGF8 signaling promotes chondrogenic rather than osteogenic development in the embryonic skull.Semantic proximity Read ↗

The clinical manifestations, molecular mechanisms and treatment of craniosynostosis.Semantic proximity Read ↗

Craniosynostosis: novel insights into pathogenesis and treatment.Semantic proximity Read ↗

Fibroblast growth factor signaling in cranial suture development and pathogenesis.Semantic proximity Read ↗

De novo mutations in the BMP signaling pathway in lambdoid craniosynostosis.Semantic proximity Read ↗

A Genetic-Pathophysiological Framework for Craniosynostosis.Semantic proximity Read ↗

De novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis.Semantic proximity Read ↗

Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies.Semantic proximity Read ↗

Bone Morphogenetic Protein (BMP) signaling in development and human diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.