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Article

Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres

1 Jun 2017

Abstract excerpt

Acquisition of replicative immortality is currently regarded as essential for malignant transformation. This is achieved by activating a telomere lengthening mechanism (TLM), either telomerase or alternative lengthening of telomeres, to counter normal telomere attrition. However, a substantial proportion of some cancer types, including glioblastomas, liposarcomas, retinoblastomas, and osteosarcomas, are...

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PMID: 28636942
DOI: 10.1016/j.celrep.2017.05.087

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