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Article

Clinical implications of epigenetic alterations in human thoracic malignancies: epigenetic alterations in lung cancer.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Shinjo Keiko, Kondo Yutaka

Abstract excerpt

Besides known genetic aberrations, epigenetic alterations have emerged as common hallmarks of many cancer types, including lung cancer. Epigenetics is a process involved in gene regulation, mediated via DNA methylation, histone modification, chromatin remodeling, and functional noncoding RNAs, which influences the accessibility of the underlying DNA to transcriptional regulatory factors that activate or repress...

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PMID: 22359296
DOI: 10.1007/978-1-61779-612-8_13

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