Missing HLA C group 1 ligand in patients with AML and MDS is associated with reduced risk of relapse and better survival after allogeneic stem cell transplantation with fludarabine and treosulfan reduced toxicity conditioning.

doi:10.1002/ajh.24827

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Article

Missing HLA C group 1 ligand in patients with AML and MDS is associated with reduced risk of relapse and better survival after allogeneic stem cell transplantation with fludarabine and treosulfan reduced toxicity conditioning.

American journal of hematology - 1 Oct 2017

Shimoni Avichai, Vago Luca, Bernardi Massimo, Yerushalmi Ronit, Peccatori Jacopo, Greco Raffaella, Shem-Tov Noga, Lo Russo Alessandro, Danylesko Ivetta, Apel Arie, Bonini Chiara, Lupo Stanghellini Maria Teresa, Nagler Arnon, Ciceri Fabio

Abstract excerpt

Reduced-toxicity conditioning with fludarabine and treosulfan is a dose-intensive regimen with enhanced anti-leukemia effect and acceptable toxicity in AML/MDS. HLA-C regulates natural-killer (NK) cell function by inhibiting Killer immunoglobulin-like receptors (KIR) and is divided into C1 and C2 epitopes. The missing-ligand theory suggests that missing recipient KIR ligands drives NK-alloreactivity after SCT, in...

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PMID: 28631269
DOI: 10.1002/ajh.24827

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