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Article

Analysis of case-parent trios for imprinting effect using a loglinear model with adjustment for sex-of-parent-specific transmission ratio distortion.

Human genetics - 1 Aug 2017

Huang Lam Opal, Infante-Rivard Claire, Labbe Aurélie

Abstract excerpt

Transmission ratio distortion (TRD) is a phenomenon where parental transmission of disease allele to the child does not follow the Mendelian inheritance ratio. TRD occurs in a sex-of-parent-specific or non-sex-of-parent-specific manner. An offset computed from the transmission probability of the minor allele in control-trios can be added to the loglinear model to adjust for TRD. Adjusting the model removes the...

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PMID: 28631064
DOI: 10.1007/s00439-017-1824-5

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TRD

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