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Article

Measuring shared variants in cohorts of discordant siblings with applications to autism.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 2017

Ye Kenny, Iossifov Ivan, Levy Dan, Yamrom Boris, Buja Andreas, Krieger Abba M, Wigler Michael

Abstract excerpt

We develop a method of analysis [affected to discordant sibling pairs (A2DS)] that tests if shared variants contribute to a disorder. Using a standard measure of genetic relation, test individuals are compared with a cohort of discordant sibling pairs (CDS) to derive a comparative similarity score. We ask if a test individual is more similar to an unrelated affected than to the unrelated unaffected sibling from...

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Identifiers

PMID: 28630308
DOI: 10.1073/pnas.1700439114
PMCID: PMC5502605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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