Article
A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity?
Biological psychiatry - 1 May 2015
Chaste Pauline, Klei Lambertus, Sanders Stephan J, Hus Vanessa, Murtha Michael T, Lowe Jennifer K, Willsey A Jeremy, Moreno-De-Luca Daniel, Yu Timothy W, Fombonne Eric, Geschwind Daniel, Grice Dorothy E, Ledbetter David H, Mane Shrikant M, Martin Donna M, Morrow Eric M, Walsh Christopher A, Sutcliffe James S, Lese Martin Christa, Beaudet Arthur L, Lord Catherine, State Matthew W, Cook Edwin H, Devlin Bernie
Abstract excerpt
BACKGROUND: Phenotypic heterogeneity in autism has long been conjectured to be a major hindrance to the discovery of genetic risk factors, leading to numerous attempts to stratify children based on phenotype to increase power of discovery studies. This approach, however, is based on the hypothesi...
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