Article

Assortative mating and parental genetic relatedness drive the pathogenicity of variably expressive variants

2023-05-26

Abstract excerpt

<h4>ABSTRACT</h4> We examined more than 38,000 spouse pairs from four neurodevelopmental disease cohorts and the UK Biobank to identify phenotypic and genetic patterns in parents associated with neurodevelopmental disease risk in children. We identified correlations between six phenotypes in parents and children, including correlations of clinical diagnoses such as obsessive-compulsive disorder (R=0.31-0.49, p<0.0...

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Literature Corpus work: 05d45a18-165c-5d9e-887e-f5a55ff08add
DOI: 10.1101/2023.05.18.23290169

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