Article
Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.
Nature genetics - 1 Aug 2017
McGinnis Ralph, Steinthorsdottir Valgerdur, Williams Nicholas O, Thorleifsson Gudmar, Shooter Scott, Hjartardottir Sigrun, Bumpstead Suzannah, Stefansdottir Lilja, Hildyard Lucy, Sigurdsson Jon K, Kemp John P, Silva Gabriela B, Thomsen Liv Cecilie V, Jääskeläinen Tiina, Kajantie Eero, Chappell Sally, Kalsheker Noor, Moffett Ashley, Hiby Susan, Lee Wai Kwong, Padmanabhan Sandosh, Simpson Nigel A B, Dolby Vivien A, Staines-Urias Eleonora, Engel Stephanie M, Haugan Anita, Trogstad Lill, Svyatova Gulnara, Zakhidova Nodira, Najmutdinova Dilbar, Dominiczak Anna F, Gjessing Håkon K, Casas Juan P, Dudbridge Frank, Walker James J, Pipkin Fiona Broughton, Thorsteinsdottir Unnur, Geirsson Reynir T, Lawlor Debbie A, Iversen Ann-Charlotte, Magnus Per, Laivuori Hannele, Stefansson Kari, Morgan Linda
Abstract excerpt
Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from...
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