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Article

Natural selection of FLT1 alleles and their association with malaria resistance in utero.

Proceedings of the National Academy of Sciences of the United States of America - 23 Sept 2008

Muehlenbachs Atis, Fried Michal, Lachowitzer Jeff, Mutabingwa Theonest K, Duffy Patrick E

Abstract excerpt

Placental malaria (PM) caused by Plasmodium falciparum contributes significantly to infant mortality in sub-Saharan Africa and is associated with pregnancy loss. We hypothesized that fetal genes that modify PM would be associated with fetal fitness. During PM, placental trophoblasts produce soluble fms-like tyrosine kinase 1 (sFlt1), also known as soluble VEGF receptor 1, an angiogenesis inhibitor associated with...

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Source

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Identifiers

PMID: 18779584
DOI: 10.1073/pnas.0803657105
PMCID: PMC2567167

Genes

FLT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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