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Genomic Insights at the Maternal-Fetal Interface: Preeclampsia Subtypes and Clinical Implications.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2025

Solt Ido, Dominsky Omri, Ben David Chen, Admati Inbal, Cohen Sarah M, Yagel Simcha

Abstract excerpt

Recent advances in single-cell transcriptomics have provided significant insights into the pathophysiology of preeclampsia, uncovering cell-type-specific gene expression changes at the maternal-fetal interface. Key discoveries include dysregulated angiogenic factors, such as elevated sFlt-1 (soluble fms-like tyrosine kinase-1) and reduced PlGF (placental growth factor), predominantly in syncytiotrophoblasts,...

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PMID: 40874308
DOI: 10.1161/ATVBAHA.125.321710

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