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Article

Reliable detection of rare mutations in EGFR gene codon L858 by PNA-LNA PCR clamp in non-small cell lung cancer.

Advances in experimental medicine and biology - 1 Jan 2013

Skronski Michal, Chorostowska-Wynimko Joanna, Szczepulska Ewa, Szpechcinski Adam, Rudzinski Piotr, Orlowski Tadeusz, Langfort Renata

Abstract excerpt

PNA-LNA PCR clamp real-time PCR method represents allele-specific approach to mutation analysis of EGFR gene in NSCLC. Due to its unique design, it is characterized by exceptionally high specificity and sensitivity but also allows detection of rare or not specifically-targeted EGFR mutations within examined exons, otherwise undetectable by other mutation-specific fluorescent probes. We herein present two cases of...

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Source

Identifiers

PMID: 22836650
DOI: 10.1007/978-94-007-4549-0_39

Genes

EGFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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