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Article

Predictive efficacy of low burden EGFR mutation detected by next-generation sequencing on response to EGFR tyrosine kinase inhibitors in non-small-cell lung carcinoma.

PloS one - 1 Jan 2013

Kim Hye Sook, Sung Jae Sook, Yang Song-Ju, Kwon Nak-Jung, Jin LiHua, Kim Seung Tae, Park Kyong Hwa, Shin Sang Won, Kim Han Kyeom, Kang Jin-Hyoung, Kim Jeong-Oh, Park Jae Yong, Choi Jin Eun, Yoon HyoungKyu, Park Chan Kwon, Yang Kap-Seok, Seo Jeong-Sun, Kim Yeul Hong

Abstract excerpt

Direct sequencing remains the most widely used method for the detection of epidermal growth factor receptor (EGFR) mutations in lung cancer; however, its relatively low sensitivity limits its clinical use. The objective of this study was to investigate the sensitivity of detecting an epidermal growth factor receptor (EGFR) mutation from peptide nucleic acid-locked nucleic acid polymerase chain reaction (PNA-LNA...

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Identifiers

PMID: 24376508
DOI: 10.1371/journal.pone.0081975
PMCID: PMC3869671

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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