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Article

Pharmacoproteomic characterisation of human colon and rectal cancer

1 Nov 2017

Abstract excerpt

Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models for proteome-guided pre-clinical drug sensitivity studies are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of > 10,000 proteins using mass spectrometry. Integration with proteomes of 90 CRC patients and matched transcriptomics data...

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PMID: 29101300
DOI: 10.15252/msb.20177701

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