Article
Primary myelofibrosis: Older age and high JAK2V617F allele burden are associated with elevated plasma high-sensitivity C-reactive protein levels and a phenotype of progressive disease.
Leukemia research - 1 Sept 2017
Barosi Giovanni, Massa Margherita, Campanelli Rita, Fois Gabriela, Catarsi Paolo, Viarengo Gianluca, Villani Laura, Poletto Valentina, Bosoni Tiziana, Magrini Umberto, Gale Robert P, Rosti Vittorio
Abstract excerpt
We measured plasma levels of high-sensitivity C-reactive protein (hs-CRP) in 526 subjects with primary myelofibrosis (PMF). Thirty-eight percent had an elevated hs-CRP level (≥0.3mg/dL). Elevated hs-CRP levels were associated with a progressive disease phenotype, including anemia, high white blood cell count, low platelet count, increased splenomegaly, increased risk of blast transformation, and worse survival....
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