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Article

Driver mutations (JAK2V617F, MPLW515L/K or CALR), pentraxin-3 and C-reactive protein in essential thrombocythemia and polycythemia vera.

Journal of hematology & oncology - 22 Feb 2017

Lussana Federico, Carobbio Alessandra, Salmoiraghi Silvia, Guglielmelli Paola, Vannucchi Alessandro Maria, Bottazzi Barbara, Leone Roberto, Mantovani Alberto, Barbui Tiziano, Rambaldi Alessandro

Abstract excerpt

BACKGROUND: The driver mutations JAK2V617F, MPLW515L/K and CALR influence disease phenotype of myeloproliferative neoplasms (MPNs) and might sustain a condition of chronic inflammation. Pentraxin 3 (PTX3) and high-sensitivity C-reactive protein (hs-CRP) are inflammatory biomarkers potentially useful for refining prognostic classification of MPNs. METHODS: We evaluated 305 with essential thrombocythemia (ET) and...

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Source

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Identifiers

PMID: 28228104
DOI: 10.1186/s13045-017-0425-z
PMCID: PMC5322581

Genes

CRP
PTX3
CALR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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