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Article

Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms.

Mediators of inflammation - 1 Jan 2015

Čokić Vladan P, Mitrović-Ajtić Olivera, Beleslin-Čokić Bojana B, Marković Dragana, Buač Marijana, Diklić Miloš, Kraguljac-Kurtović Nada, Damjanović Svetozar, Milenković Pavle, Gotić Mirjana, Raj Puri K

Abstract excerpt

The recent JAK1/2 inhibitor trial in myeloproliferative neoplasms (MPNs) showed that reducing inflammation can be more beneficial than targeting gene mutants. We evaluated the proinflammatory IL-6 cytokine and JAK-STAT signaling pathway related genes in circulating CD34(+) cells of MPNs. Regarding laboratory data, leukocytosis has been observed in polycythemia vera (PV) and JAK2V617F mutation positive versus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26491227
DOI: 10.1155/2015/453020
PMCID: PMC4602333

Genes

AKT2
CCND3
IFNGR2
JAK1
PIM1
PTPN11
STAT1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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