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Article

Identification of patients with poorer survival in primary myelofibrosis based on the burden of JAK2V617F mutated allele.

Blood - 20 Aug 2009

Guglielmelli Paola, Barosi Giovanni, Specchia Giorgina, Rambaldi Alessandro, Lo Coco Francesco, Antonioli Elisabetta, Pieri Lisa, Pancrazzi Alessandro, Ponziani Vanessa, Delaini Federica, Longo Giovanni, Ammatuna Emanuele, Liso Vincenzo, Bosi Alberto, Barbui Tiziano, Vannucchi Alessandro M

Abstract excerpt

A total of 186 patients with primary myelofibrosis (PMF) were genotyped for JAK2V617F at diagnosis aimed at analyzing the correlation of mutational status and mutated allele burden with outcome variables, including time to anemia, leukocytosis, leukopenia, thrombocytopenia, massive splenomegaly, leukemia, and with overall survival. A total of 127 JAK2V617F-mutated patients (68% of whole series) were divided in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19549988
DOI: 10.1182/blood-2009-04-216044

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Identification of patients with poorer survival in primary myelofibrosis based on the burden of JAK2V617F mutated allele.PMID 19549988Read ↗

Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival.Semantic proximity Read ↗

JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis.Semantic proximity Read ↗

JAK2(V617F) allele burden discriminates essential thrombocythemia from a subset of prefibrotic-stage primary myelofibrosis.Semantic proximity Read ↗

The JAK2V617F tyrosine kinase mutation has no impact on overall survival and the risk of leukemic transformation in myelofibrosis.Semantic proximity Read ↗

The JAK2 V617F allele burden in essential thrombocythemia, polycythemia vera and primary myelofibrosis--impact on disease phenotype.Semantic proximity Read ↗

The presence of JAK2V617F in primary myelofibrosis or its allele burden in polycythemia vera predicts chemosensitivity to hydroxyurea.Semantic proximity Read ↗

EZH2 mutational status predicts poor survival in myelofibrosis.Semantic proximity Read ↗

Clinical Impact of JAK2V617F Allele Burden in Philadelphia-Negative Myeloproliferative NeoplasmsSemantic proximity Read ↗

Comparison of JAK2V617F -positive essential thrombocythaemia and early primary myelofibrosis: The impact of mutation burden and histology.Semantic proximity Read ↗

JAK2 allele burden in the myeloproliferative neoplasms: effects on phenotype, prognosis and change with treatmentSemantic proximity Read ↗

Prognostic impact of bone marrow fibrosis in primary myelofibrosis. A study of the AGIMM group on 490 patients.Semantic proximity Read ↗

[Clinical significance of the quantification of JAK2V617F allele burden in classical Ph-negative myeloproliferative neoplasms].Semantic proximity Read ↗

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