Article
Use of telomerase promoter mutations to mark specific molecular subsets with reciprocal clinical behavior in IDH mutant and IDH wild-type diffuse gliomas.
Journal of neurosurgery - 1 Apr 2018
Akyerli Cemaliye B, Yüksel Şirin, Can Özge, Erson-Omay E Zeynep, Oktay Yavuz, Coşgun Erdal, Ülgen Ege, Erdemgil Yiğit, Sav Aydın, von Deimling Andreas, Günel Murat, Yakıcıer M Cengiz, Pamir M Necmettin, Özduman Koray
Abstract excerpt
OBJECTIVE Recent studies have established that hemispheric diffuse gliomas may be grouped into subsets on the basis of molecular markers; these subsets are loosely correlated with the histopathological diagnosis but are strong predictors of clinical tumor behavior. Based on an analysis of molecular and clinical parameters, the authors hypothesized that mutations of the telomerase promoter (TERTp-mut) mark...
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