Article
Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-β in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2017
Tojais Nancy F, Cao Aiqin, Lai Ying-Ju, Wang Lingli, Chen Pin-I, Alcazar Miguel A Alejandre, de Jesus Perez Vinicio A, Hopper Rachel K, Rhodes Christopher J, Bill Matthew A, Sakai Lynn Y, Rabinovitch Marlene
Abstract excerpt
OBJECTIVE: We determined in patients with pulmonary arterial (PA) hypertension (PAH) whether in addition to increased production of elastase by PA smooth muscle cells previously reported, PA elastic fibers are susceptible to degradation because of their abnormal assembly. APPROACH AND RESULTS: Fi...
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