Article
A type V myosin (Myo2p) and a Rab-like G-protein (Ypt11p) are required for retention of newly inherited mitochondria in yeast cells during cell division.
Molecular biology of the cell - 1 Sept 2004
Boldogh Istvan R, Ramcharan Sharmilee L, Yang Hyeong-Cheol, Pon Liza A
Abstract excerpt
Two actin-dependent force generators contribute to mitochondrial inheritance: Arp2/3 complex and the myosin V Myo2p (together with its Rab-like binding partner Ypt11p). We found that deletion of YPT11, reduction of the length of the Myo2p lever arm (myo2-Delta6IQ), or deletion of MYO4 (the other yeast myosin V), had no effect on mitochondrial morphology, colocalization of mitochondria with actin cables, or the...
Topics
- Actins
- Base Sequence
- Cell Division
- DNA, Fungal
- Gene Deletion
- Genes, Fungal
- Mitochondria
- Mutation
- Myosin Heavy Chains
- Myosin Type V
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- rab GTP-Binding Proteins