Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline factor DDX4 functions in blood-derived cancer cell phenotypes.

Cancer science - 1 Aug 2017

Schudrowitz Natalie, Takagi Satoshi, Wessel Gary M, Yajima Mamiko

Abstract excerpt

DDX4 (the human ortholog of Drosophila Vasa) is an RNA helicase and is present in the germ lines of all metazoans tested. It was historically thought to be expressed specifically in germline, but with additional organisms studied, it is now clear that in some animals DDX4/Vasa functions outside of the germline, in a variety of somatic cells in the embryo and in the adult. In this report, we document that DDX4 is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Movement
Share to DEAD-box RNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Gene Knockout Techniques

Share to Leukemia

Share to Multiple Myeloma

Share to Spindle Apparatus

Source

Open in PubMed Open full text

Identifiers

PMID: 28612512
DOI: 10.1111/cas.13299
PMCID: PMC5543511

Genes

DDX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline factor DDX4 functions in blood-derived cancer cell phenotypes.PMID 28612512Read ↗

Germline and Somatic Defects in DDX41 and its Impact on Myeloid NeoplasmsSemantic proximity Read ↗

Clinical and mechanistic insights into the roles of DDX41 in haematological malignancies.Semantic proximity Read ↗

The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cellsSemantic proximity Read ↗

Loss-of-function Mutations K11E or E271K Lead to Novel Tumor Suppression, Implicate Nucleolar Helicase DDX24 Oncogenicity.Semantic proximity Read ↗

DDX41 dissolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell deathSemantic proximity Read ↗

Actin-related ACTL8 localizes to the nucleus and modulates locus-specific transcription through chromatin regulationSemantic proximity Read ↗

Drosophila Axud1 is involved in the control of proliferation and displays pro-apoptotic activity.Semantic proximity Read ↗

A conserved germline-specific Dsn1 alternative splice isoform supports oocyte and embryo developmentSemantic proximity Read ↗

DDX41 is needed for pre- and postnatal hematopoietic stem cell differentiation in miceSemantic proximity Read ↗

DDX1 is required for testicular tumorigenesis, partially through the transcriptional activation of 12p stem cell genesSemantic proximity Read ↗

Comprehensive summary: the role of PBX1 in development and cancersSemantic proximity Read ↗

Antagonism among DUX family members evolved from an ancestral toxic single homeodomain proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.