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Article

Quantitative and qualitative iNKT repertoire associations with disease susceptibility and outcome in macaque tuberculosis infection.

Tuberculosis (Edinburgh, Scotland) - 1 Jul 2017

Chancellor Andrew, White Andrew, Tocheva Anna S, Fenn Joe R, Dennis Mike, Tezera Liku, Singhania Akul, Elliott Tim, Tebruegge Marc, Elkington Paul, Gadola Stephan, Sharpe Sally, Mansour Salah

Abstract excerpt

Correlates of immune protection that reliably predict vaccine efficacy against Mycobacterium tuberculosis (Mtb) infection are urgently needed. Invariant NKT cells (iNKTs) are CD1d-dependent innate T cells that augment host antimicrobial immunity through production of cytokines, including interferon (IFN)-γ and tumour necrosis factor (TNF)-α. We determined peripheral blood iNKT numbers, their proliferative...

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Identifiers

PMID: 28610792
DOI: 10.1016/j.tube.2017.04.011
PMCID: PMC6168056

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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