Article
Whole-exome sequencing identifies genes associated with Tourette's disorder in multiplex families.
Molecular psychiatry - 1 Nov 2021
Cao Xiaolong, Zhang Yeting, Abdulkadir Mohamed, Deng Li, Fernandez Thomas V, Garcia-Delgar Blanca, Hagstrøm Julie, Hoekstra Pieter J, King Robert A, Koesterich Justin, Kuperman Samuel, Morer Astrid, Nasello Cara, Plessen Kerstin J, Thackray Joshua K, Zhou Lisheng, Dietrich Andrea, Tischfield Jay A, Heiman Gary A, Xing Jinchuan
Abstract excerpt
Tourette's Disorder (TD) is a neurodevelopmental disorder (NDD) that affects about 0.7% of the population and is one of the most heritable NDDs. Nevertheless, because of its polygenic nature and genetic heterogeneity, the genetic etiology of TD is not well understood. In this study, we combined the segregation information in 13 TD multiplex families with high-throughput sequencing and genotyping to identify genes...
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