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Article

Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis.

Cancer research - 15 Feb 2009

Ricono Jill M, Huang Miller, Barnes Leo A, Lau Steven K, Weis Sara M, Schlaepfer David D, Hanks Steven K, Cheresh David A

Abstract excerpt

Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. Previously, we showed that epidermal growth factor (EGF) stimulation of pancreatic carcinoma cells led to invasion and metastasis that was blocked by antagonists of integrin alpha(v)beta(5). Here, we show that EGF stimulates metastasis of carcinoma cells via a Src-dependent phosphorylation of p130 CAS leading to...

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Identifiers

PMID: 19208836
DOI: 10.1158/0008-5472.CAN-08-3612
PMCID: PMC2741736

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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