Article
The integrin-extracellular matrix axis in pancreatic cancer.
Pancreas - 1 Nov 2007
Grzesiak John J, Ho Jason C, Moossa Abdool R, Bouvet Michael
Abstract excerpt
Pancreatic cancer is the fifth leading cause of adult cancer death in the United States, with 5-year survival rates of only 1% to 4%. Current therapeutic strategies generally result in only a few months of extended life. Recent evidence from several independent laboratories in vitro and in vivo indicate that integrin-mediated cell attachment to the extracellular matrix (ECM), components of which are highly...
Topics
- Animals
- Antineoplastic Agents
- Biomedical Research
- Cell Proliferation
- Collagen Type I
- Extracellular Matrix
- Humans
- Integrins
- Neoplasm Invasiveness
- Pancreatic Neoplasms
- Phenotype
- Signal Transduction