Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrin α6β4 in Colorectal Cancer: Expression, Regulation, Functional Alterations and Use as a Biomarker

21 Dec 2019

Abstract excerpt

Integrin α6β4 is one of the main laminin receptors and is primarily expressed by epithelial cells as an active component of hemidesmosomes. In this article, after a brief summary about integrins in the gut epithelium in general, I review the knowledge and clinical potential of this receptor in human colorectal cancer (CRC) cells. Most CRC cells overexpress both α6 and β4 subunits, in situ in primary tumours as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caveolin-1 and cellular processes
Share to Cell Adhesion Molecules Research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31877793
DOI: 10.3390/cancers12010041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrin α6β4 in Colorectal Cancer: Expression, Regulation, Functional Alterations and Use as a BiomarkerPMID 31877793Read ↗

Integrin α6A splice variant regulates proliferation and the Wnt/β-catenin pathway in human colorectal cancer cellsSemantic proximity Read ↗

Integrin α6Bβ4 inhibits colon cancer cell proliferation and c-Myc activitySemantic proximity Read ↗

Integrin α1 promotes tumorigenicity and progressive capacity of colorectal cancerSemantic proximity Read ↗

Integrin β4 as a Potential Diagnostic and Therapeutic Tumor MarkerSemantic proximity Read ↗

Integrin α5 subunit is required for the tumor supportive role of fibroblasts in colorectal adenocarcinoma and serves as a potential stroma prognostic markerSemantic proximity Read ↗

Regulation and Functions of α6-Integrin (CD49f) in Cancer BiologySemantic proximity Read ↗

ITGB4 is a novel prognostic factor in colon cancerSemantic proximity Read ↗

Integrins as mediators of epithelial cell-matrix interactions in the human small intestinal mucosaSemantic proximity Read ↗

Integrin α1β1 expression is controlled by c-MYC in colorectal cancer cellsSemantic proximity Read ↗

Expression of Functionally Distinct Variants of the β4A Integrin Subunit in Relation to the Differentiation State in Human Intestinal CellsSemantic proximity Read ↗

Integrinβ-1 in disorders and cancers: molecular mechanisms and therapeutic targetsSemantic proximity Read ↗

Integrins Within the Tumor Microenvironment: Biological Functions and Advances in Therapeutic Targeting <strong> </strong>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.