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Article

HPV/E7 induces chemotherapy‐mediated tumor suppression by ceramide‐dependent mitophagy

12 Jun 2017

Abstract excerpt

Human papillomavirus (HPV) infection is linked to improved survival in response to chemo-radiotherapy for patients with oropharynx head and neck squamous cell carcinoma (HNSCC). However, mechanisms involved in increased HNSCC cell death by HPV signaling in response to therapy are largely unknown. Here, using molecular, pharmacologic and genetic tools, we show that HPV early protein 7 (E7) enhances...

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PMID: 28606997
DOI: 10.15252/emmm.201607088

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