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Article

Anticancer Drugs Aimed at E6 and E7 Activity in HPV-Positive Cervical Cancer

25 Jan 2012

Abstract excerpt

Standard treatment of locally advanced cervical cancer currently consists of concurrent chemoradiation, leading to a 5-year disease-free survival of 66-79%, indicating that there is still ample room for improvement. Characteristic of cervical cancer is the presence of high risk (HR) human papillomavirus (HPV) DNA in more than 99% of these tumors. When the HR HPV genome integrates into the host genome, oncogenic...

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PMID: 22165971
DOI: 10.2174/156800912799095135

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